Objective: To study patterns and outcomes of IHCA. Setting: Tertiary care centre in the southern region of Saudi Arabia. Design: Retrospective case-series study. Methods: Patients aged ≥12 years exhibiting IHCA and subjected to the hospital protocol including CPR from January 2014 to July 2017 were enrolled. Results: The study included 700 patients with a mean age of 59 years (range, 12–103 years; 59% males). Cardiac arrest occurred in 93% of patients, while 7% presented with respiratory arrest. The majority (94%) of cardiac arrest cases were asystole, followed by ventricular fibrillation (3%), pulseless electrical activity (2%), and pulseless ventricular tachycardia (1%). Of the arrest rhythms, 4% were classified as shockable. Overall return to spontaneous circulation occurred in 36.9% of cases. A logistic regression model revealed that age, need of mechanical ventilation, and CPR duration were the most significant predictors of survival among the arrested patients. Conclusions: Asystole was the predominating arrest rhythm in patients with IHCA. CPR duration, age, and need of mechanical ventilation are the main predictors of survival.