Objectives: To assess the prevalence of dyslipidemia and to identify its association with obesity among Saudi adults attending a primary health care center in Abha City, Saudi Arabia. Subjects and Methods: This study followed a cross-sectional study design. A consecutive sample was applied to screen 457 apparently healthy Saudi adults aged above 20 years. Participants’ weight and height were assessed and their body mass index (BMI) was calculated. Results: Regarding dyslipidemia, 17.3% had hypercholesterolemia, 5% had hypertriglyceridemia, 47.9% had low HDL- C serum levels, 17.9% had high LDL-C serum levels, 12.3% had TC/HDL-C ratio >6, 30.9% had TG/HDL-C ratio >3.8 and 23.2% had LDL-C/HDL-C ratio >3.3. Male participants had significantly higher proportions of hypercholesterolemia, high LDL-C and TC/HDL-C ratio than females (20.9% and 10.9%, respectively, p=0.007 for hypercholesterolemia; 20.9%; and 12.7%, respectively, p=0.029 for high LDL-C and 15.8% and 6.1%, respectively, p=0.002 for TC/HDL-C). LDL-C serum levels were lowest among elderly participants and highest among youngest participants (p=0.007). Hypercholesterolemia, hypertriglyceridemia, LDL-C, TC/HDL-C ratio, TG/HDL-C ratio and LDL-C/HDL-C ratio were highest among obese and overweight participants (29.1% and 14.2%, respectively, p<0.001 for hypercholesterolemia; 8.2% and 5.3%, respectively, p=0.018 for hypertriglyceridemia; 26.9% and 14.2%, respectively, p=0.006, for LDL-C; 18.7% and 11.9%, respectively, p=0.004, for TC/HDL-C; 40.3% and 28.3%, respectively, p=0.014 for TG/HDL-C ratio; and 31.3% and 24.3%, respectively, p<0.001 for LDL-C/HDL-C ratio). Participants’ HDL-C and LDL-C serum levels differed significantly according to their family history of dyslipidemia (p=0.046 and p<0.001, respectively). Conclusions: Prevalence of dyslipidemia is high among Saudi adults attending primary health care centers, especially among males, obese and elderly subjects in addition to those with positive family history of dyslipidemia. Community-based intervention strategies are needed to prevent and manage cardiovascular risk factors. Health education for attendants of primary health care centers regarding healthier lifestyles should be emphasized.